Bacterial vaccine vectors and bacillus Calmette-Gurin.

abstract

• Recent advances in biotechnology now allow a more modern approach to the development of vaccines, particularly that of recombinant vaccines. Bacterial vaccine vectors have the advantage over viral vectors in that the former have the ability to express a greater number of antigens in different forms. Although no recombinant bacterial vaccines are currently in use, bacillus Calmette-Gurin (BCG), Salmonella species, and Escherichia coli are being developed as vaccine vectors. We review plasmid systems and mutant strains developed for the expression of foreign antigens, with particular emphasis on those developed for BCG. We describe the development of antigen expression systems as well as the immune response elicited by recombinant BCG vaccine strains to bacterial and human immunodeficiency virus (HIV) antigens. A modified recombinant BCG carrier with selection for the stable maintenance of rDNA is proposed.

authors

• Cirillo, Jeffrey

published proceedings

• Clin Infect Dis

altmetric score

• 9

author list (cited authors)

• Cirillo, J. D., Stover, C. K., Bloom, B. R., Jacobs, W. R., & Barletta, R. G.

citation count

• 36

complete list of authors

• Cirillo, JD||Stover, CK||Bloom, BR||Jacobs, WR||Barletta, RG

publication date

• April 1995

publisher

• Oxford University Press (OUP)  Publisher

published in

• Clinical Infectious Diseases  Journal

keywords

• Administration, Oral
• Antigens, Bacterial
• BCG Vaccine
• Bacteria
• Base Sequence
• DNA, Ribosomal
• Drug Carriers
• Humans
• Molecular Sequence Data
• Mycobacterium
• Mycobacterium Infections
• Plasmids
• Tuberculosis
• Vaccines, Synthetic

PubMed Central ID

• 7795044

Digital Object Identifier (DOI)

• 10.1093/clinids/20.4.1001

start page

• 1001

end page

• 1009

volume

• 20

issue

• 4

URL

• http://dx.doi.org/10.1093/clinids/20.4.1001

user-defined tag

• 3 Good Health and Well-Being