Khanna, Deepesh (2016-05). Effects of Exercise and Diet-Induced Weight Loss in Sedentary Obese Women on Inflammatory Markers, Resistin and Visfatin. Doctoral Dissertation.
Thesis
Resistin and visfatin are secreted by adipose tissue and are potential regulators of inflammation and insulin sensitivity. This study examined the effects of exercise and diet-induced weight loss on resistin and visfatin. Twenty six sedentary obese women were randomly assigned into control group (C) or an exercise plus diet group (DE) that involved circuit resistance-exercise (4 d/week) with walking (10,000 steps/d, 3 d/week) while consuming 1,200 kcal/day for 1 week and 1,500 kcal/d diet for 11 weeks consisting of 45:30 % Protein:Carbohydrate. Body composition and fasting blood samples were obtained and analyzed by MANOVA and Pearson correlation analysis. Data are presented as mean+-SD changes from baseline. Participants in the DE group lost more weight (DE: -5.9+-4.0; C: 0.64+-1.4 kg, p<0.001) and fat (DE: -5.1+-4.5; C: 0.4+-1.5 kg, p=0.001). Significant differences were seen between groups in leptin (DE: -17.8+-21.9; C: 4.5+-16.0 ng/ml, p=0.003), IL-6 (DE: -1.9+-4.2; C: 2.7+-1.2 ng/ml, p=0.001) and TNF-? (DE: -.2+-2.1; C: 1.7+-1.5 ng/ml, p=0.013) while visfatin (DE: 0.85+-14.9; C: 20.2+-37.1 ng/ml, p=0.10) and insulin (DE: -8.5+-15.0; C: 0.12+-7.7 IU/ml, p=0.07) tended to differ between groups. No significant differences were seen in changes in resistin (DE: 18.6+-100; C: 59.9+-162.2 ng/ml, p=0.452) or glucose (DE: -3.8+-19.8; C: -2.8+-6.9 %, p=0.87). Significant correlations were seen between changes in IL-6 and resistin (r=0.430, p=0.028) and changes in resistin and visfatin (r=0.417, p=0.034). These findings indicate that exercise and diet-induced weight loss have an effect on resistin and visfatin.
