Addiction neuroscience goes nuclear: A role for the transcription factor RXR.

abstract

• Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron1 on the role of a specific nuclear receptor, RXR. Results demonstrate that modifying accumbens RXR expression profoundly alters gene transcription, neuronal activity, and cocaine-induced behavioral responses.

authors

• Swinford-Jackson, Sarah

published proceedings

• Neuron

author list (cited authors)

• Pierce, R. C., Rich, M. T., & Swinford-Jackson, S. E.

complete list of authors

• Pierce, R Christopher||Rich, Matthew T||Swinford-Jackson, Sarah E

publication date

• May 2023

publisher

• Elsevier  Publisher

published in

• Neuron  Journal

keywords

• Animals
• COCAINE
• Cell Nucleus
• Gene Expression Regulation
• Mice
• Receptors, Cytoplasmic And Nuclear
• Retinoid X Receptor Alpha
• Transcription Factors

PubMed Central ID

• 37141859

Digital Object Identifier (DOI)

• 10.1016/j.neuron.2023.04.002

start page

• 1351

end page

• 1353

volume

• 111

issue

• 9

URL

• https://doi.org/10.1016/j.neuron.2023.04.002