Deep brain stimulation for psychostimulant use disorders.

abstract

• Safe and effective therapeutics for psychostimulant use disorders remain elusive. Deep brain stimulation (DBS), which is FDA-approved for other indications, is a promising candidate for treating severe substance use disorders. We examine the clinical and preclinical evidence for DBS of the nucleus accumbens as a possible therapeutic option for cocaine and methamphetamine use disorders. Limitations of the literature to date, including the lack of females included in studies evaluating the efficacy of DBS, and new strategies to optimize brain stimulation approaches are also discussed.

authors

• Swinford-Jackson, Sarah

published proceedings

• J Neural Transm (Vienna)

author list (cited authors)

• Swinford-Jackson, S. E., & Pierce, R. C.

complete list of authors

• Swinford-Jackson, Sarah E||Pierce, R Christopher

publication date

• May 2024

publisher

• Springer Nature  Publisher

published in

• JOURNAL OF NEURAL TRANSMISSION  Journal

keywords

• Amphetamine-Related Disorders
• Animals
• COCAINE
• Central Nervous System Stimulants
• Cocaine-Related Disorders
• Deep Brain Stimulation
• Humans
• Methamphetamine
• Nucleus Accumbens
• Substance Use Disorders
• Substance-Related Disorders

PubMed Central ID

• 37823965

Digital Object Identifier (DOI)

• 10.1007/s00702-023-02706-6

start page

• 469

end page

• 473

volume

• 131

issue

• 5

URL

• https://doi.org/10.1007/s00702-023-02706-6