Flash Communication: Flexibility of a Biologically Inspired Ligand Framework for Intramolecular C-H Activation.

abstract

• High-valent iron complexes play a crucial role in the oxidation of organic substrates, especially in C-H bond functionalization reactions in biology. This paper investigates the reactivity of nonporphyrin tripodal ligands featuring a secondary coordination sphere, focusing on their prospective ability to stabilize high-valent iron-oxo species. Using NMR spectroscopy and X-ray crystallography, we detail the formation of an Fe(III)-alkoxide complex through intramolecular C-H bond activation, providing insight into the potential transient formation of a high-valent iron-oxo intermediate. While attempts to observe an Fe(IV)-oxo complex were unsuccessful, our findings underscore the significance of the ligand electronic environment in stabilizing reactive iron species for C-H bond activation.

authors

• Fout, Alison

published proceedings

• Organometallics

author list (cited authors)

• Moore, J. M., Park, Y. J., & Fout, A. R.

complete list of authors

• Moore, Jewelianna M||Park, Yun Ji||Fout, Alison R

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organometallics  Journal

keywords

• 34 Chemical Sciences
• 3402 Inorganic Chemistry

PubMed Central ID

• 39949504

Digital Object Identifier (DOI)

• 10.1021/acs.organomet.4c00454

start page

• 472

end page

• 476

volume

• 44

issue

• 3

URL

• https://doi.org/10.1021/acs.organomet.4c00454