Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia.

abstract

• The intravenous secretin test is widely used to distinguish gastrinoma (Zollinger-Ellison syndrome) from other causes of fasting hypergastrinemia. We report 2 patients with fasting hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin. Both patients had pentagastrin-fast achlorhydria. Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. Gastric acid secretion should be measured in hypergastrinemic patients before embarking on a secretin test.

authors

• Schiller, Lawrence

published proceedings

• Gastroenterology

author list (cited authors)

• Feldman, M., Schiller, L. R., Walsh, J. H., Fordtran, J. S., & Richardson, C. T.

complete list of authors

• Feldman, M||Schiller, LR||Walsh, JH||Fordtran, JS||Richardson, CT

publisher

• Elsevier  Publisher

published in

• Gastroenterology  Journal

keywords

• Achlorhydria
• Cross Reactions
• False Positive Reactions
• Female
• Gastrins
• Humans
• Middle Aged
• Secretin
• Zollinger-ellison Syndrome

PubMed Central ID

• 3582916

Digital Object Identifier (DOI)

• 10.1016/0016-5085(87)90314-3

start page

• 59

end page

• 62

volume

• 93

issue

• 1