Ranitidine potentiates ileum contractions caused by GABA and electrical stimulation. Academic Article

abstract

• GABA-evoked contractions of the guinea pig ileum were significantly potentiated by the histamine H2-receptor antagonist ranitidine in concentrations above 10 microM. To help define the mechanism of this interaction, the present study compared the effects of ranitidine on contractile responses of the guinea pig ileum to GABA, acetylcholine (A Ch) and electrical stimulation of intrinsic cholinergic neurons. Ranitidine, at concentrations that potentiated responses to GABA, also potentiated contractions induced by transmural electrical stimulation. The ability of ranitidine to amplify these latter responses was antagonized by atropine. Contractile responses to exogenous A Ch, however, were unaffected by ranitidine at any concentration. These results suggest that prejunctional, rather than postjunctional mechanisms, are of primary importance in the interaction between ranitidine and GABA.

authors

• Trzeciakowski, Jerome

published proceedings

• Life Sci

author list (cited authors)

• Trzeciakowski, J. P., & Cole, S.

citation count

• 3

complete list of authors

• Trzeciakowski, JP||Cole, S

publication date

• January 1986

publisher

• Elsevier  Publisher

published in

• LIFE SCIENCES  Journal

keywords

• Animals
• Cimetidine
• Dose-Response Relationship, Drug
• Drug Synergism
• Electric Stimulation
• Female
• Gamma-Aminobutyric Acid
• Guinea Pigs
• Ileum
• In Vitro Techniques
• Male
• Muscle Contraction
• Parasympathetic Nervous System
• Physostigmine
• Ranitidine
• Receptors, GABA-A

Digital Object Identifier (DOI)

• 10.1016/0024-3205(86)90009-3

start page

• 173

end page

• 182

volume

• 38

issue

• 2

URL

• http://dx.doi.org/10.1016/0024-3205(86)90009-3