Commentary: will analyzing the epigenome yield cohesive principles of ethanol teratology? Academic Article

abstract

• This commentary discusses the impact of the manuscript by Zhou etal., titled "Alcohol Alters DNA Methylation Patterns and Inhibits Neural Stem Cell Differentiation," published in the April 2011 issue of Alcoholism: Clinical and Experimental Research (volume 35, issue 4, pages 1-12). In this manuscript, the authors present intriguing evidence from a genome scale analysis of promoter DNA methylation patterns in a class of neural crest stem cells associated with dorsal root ganglia, showing that ethanol essentially prevents epigenetic programming associated with neural stem cell differentiation. This manuscript presents several interesting and novel pieces of data and raises important questions for future research. The implications of these data for our understanding of the etiology of fetal alcohol spectrum disorders are discussed.

authors

• Miranda, Rajesh

published proceedings

• Alcohol Clin Exp Res

author list (cited authors)

• Miranda, R. C.

citation count

• 4

complete list of authors

• Miranda, Rajesh C

publication date

• July 2011

publisher

• Wiley  Publisher

published in

• Alcoholism: Clinical and Experimental Research  Journal

keywords

• Central Nervous System Depressants
• DNA Methylation
• Epigenesis, Genetic
• Ethanol
• Humans
• Neural Stem Cells
• Neurogenesis

PubMed Central ID

• 21554338

Digital Object Identifier (DOI)

• 10.1111/j.1530-0277.2011.01541.x

start page

• 1201

end page

• 1203

volume

• 35

issue

• 7

URL

• http://dx.doi.org/10.1111/j.1530-0277.2011.01541.x