Calcium channel types mediating synaptic transmission during aging. Academic Article

abstract

• The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxins reduced synaptic transmissions similarly in both age groups while nicardipine showed no effect. These results suggests that the well documented age-related changes in synaptic transmissions in the hippocampus cannot be explained by changes in the types of Ca2+ channel mediating synaptic transmission.

authors

• Griffith, William

published proceedings

• Brain Res

author list (cited authors)

• Hall, S. C., & Griffith, W. H.

citation count

• 2

complete list of authors

• Hall, SC||Griffith, WH

publication date

• January 1997

publisher

• Elsevier  Publisher

published in

• BRAIN RESEARCH  Journal

keywords

• Agatoxins
• Aging
• Animals
• Calcium Channel Blockers
• Calcium Channels
• Male
• Membrane Potentials
• Nicardipine
• Omega-Conotoxin GVIA
• Peptides
• Rats
• Rats, Inbred F344
• Spider Venoms
• Synaptic Transmission

PubMed Central ID

• 9037430

Digital Object Identifier (DOI)

• 10.1016/s0006-8993(96)01234-6

start page

• 339

end page

• 342

volume

• 745

issue

• 1-2