Histamine mediation of nicotine effects on postganglionic sympathetic neuroeffector junctions. Academic Article uri icon


  • The sympathomimetic action of nicotine was investigated using preparations of the rat pineal gland and the rabbit pulmonary artery. Nicotine (0.01-1 mM) did not stimulate N-acetyltransferase activity in pineal glands which contained functional sympathetic nerve endings. In the pulmonary artery preparation the previously described contractile effects of nicotine were antagonized by the antihistaminic compound chlorpheniramine. It is therefore postulated that histamine is involved in the sympathomimetic effects of nicotine on the pulmonary artery. 1976.

published proceedings

  • Neuropharmacology

author list (cited authors)

  • Chiou, C. Y., & Trzeciakowski, J.

citation count

  • 6

complete list of authors

  • Chiou, CY||Trzeciakowski, J

publication date

  • January 1976