Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug.

abstract

• N-Demethylated carbachol (DMC) was synthesized and analyzed for its ocular effects. DMC has been found to penetrate ocular tissue effectively. It has been shown to be free of acute toxic properties in rabbits and dogs at therapeutic doses and has been demonstrated to lower intraocular pressure of glaucomatous beagles without causing intense miosis. The effects of DMC and pilocarpine on outflow facility were compared in normal dogs. At the dose used in these experiments, both drugs affected outflow facility to a similar extent. It is concluded that DMC could be a potentially useful ocular hypotensive agent.

authors

• Trzeciakowski, Jerome

published proceedings

• Invest Ophthalmol Vis Sci

author list (cited authors)

• Chiou, C. Y., Trzeciakowski, J., & Gelatt, K. N.

citation count

• 12

complete list of authors

• Chiou, CY||Trzeciakowski, J||Gelatt, KN

publication date

• October 1980

published in

• Investigative Ophthalmology and Visual Science  Journal

keywords

• Animals
• Carbachol
• Dogs
• Glaucoma
• Intraocular Pressure
• Parasympathomimetics
• Pilocarpine
• Rabbits

PubMed Central ID

• 7419372

start page

• 1198

end page

• 1203

volume

• 19

issue

• 10