Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study. Academic Article uri icon

abstract

  • OBJECTIVE: To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. STUDY DESIGN: Retrospective, cohort study of infants <32 weeks' GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities. RESULTS: 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49-0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50-0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72-1.71]). No differences between groups were observed in rates of morbidities. CONCLUSION: Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.

published proceedings

  • J Perinatol

author list (cited authors)

  • Vaz Ferreira, C., Caro, J., Villarroel, L., Muoz, S., Alvarez, P., Flores, G., ... NEOCOSUR Neonatal Network.

complete list of authors

  • Vaz Ferreira, Catalina||Caro, Jose||Villarroel, Luis||Muñoz, Sergio||Alvarez, Patricia||Flores, Gerardo||Herrera, Tamara||Toso, Alberto||Toso, Paulina||Tapia, Jose L