Fiber optic microendoscopy for preclinical study of bacterial infection dynamics Academic Article uri icon

abstract

  • We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 10(4) and 10(7) colony forming units, respectively.

author list (cited authors)

  • Mufti, N., Kong, Y., Cirillo, J. D., & Maitland, K. C.

citation count

  • 15

publication date

  • April 2011