Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis. Academic Article uri icon

abstract

  • Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics can make treatments less effective in some cases. We tested selected oligopeptoids--previously reported as mimics of natural host defense peptides--for activity against Mycobacterium tuberculosis and assessed their cytotoxicity. A tetrameric, alkylated, cationic peptoid (1-C13(4mer)) was most potent against M. tuberculosis and least cytotoxic, whereas an unalkylated analogue, peptoid 1(4mer), was inactive. Peptoid 1-C13(4mer) thus merits further study as a potential antituberculosis drug.

published proceedings

  • Antimicrob Agents Chemother

altmetric score

  • 6

author list (cited authors)

  • Kapoor, R., Eimerman, P. R., Hardy, J. W., Cirillo, J. D., Contag, C. H., & Barron, A. E.

citation count

  • 75

complete list of authors

  • Kapoor, Rinki||Eimerman, Patrick R||Hardy, Jonathan W||Cirillo, Jeffrey D||Contag, Christopher H||Barron, Annelise E

publication date

  • June 2011