Studies of action mechanism of antiglaucoma drugs with a newly developed cat model. Academic Article

abstract

• A variety of ocular hypotensive drugs were tested in a new cat model that allows continuous, simultaneous and instantaneous determinations of aqueous humor (AH) formation and outflow to be made. Aside from pilocarpine, which only increased AH outflow, or acetazolamide and timolol, which only decreased AH formation other adrenergic agents tested decreased both AH formation and AH outflow. These findings are compared with previous results reported in the literature and their significance for glaucoma therapy is discussed. 1980.

authors

• Trzeciakowski, Jerome

published proceedings

• Life Sci

author list (cited authors)

• Chiou, G. C., Liu, H. K., & Trzeciakowski, J.

citation count

• 9

complete list of authors

• Chiou, GC||Liu, HK||Trzeciakowski, J

publication date

• January 1980

publisher

• Elsevier  Publisher

published in

• LIFE SCIENCES  Journal

keywords

• Acetazolamide
• Animals
• Aqueous Humor
• Cats
• Disease Models, Animal
• Epinephrine
• Glaucoma
• Intraocular Pressure
• Isoproterenol
• Norepinephrine
• Pilocarpine
• Propanolamines
• Propranolol
• Timolol

Digital Object Identifier (DOI)

• 10.1016/0024-3205(80)90520-2

start page

• 2445

end page

• 2451

volume

• 27

issue

• 25-26

URL

• http://dx.doi.org/10.1016/0024-3205(80)90520-2