Reduced parasitemia observed with erythrocytes containing inositol hexaphosphate. Academic Article

abstract

• Chemicals entrapped in erythrocytes by hypotonic hemolysis can be assessed for possible antiparasitic activity both in vivo and in vitro, regardless of whether they are able to diffuse into erythrocytes readily. Inositol hexaphosphate, a highly charged compound, produced a dramatic lowering of the percentage of cells infected by Babesia microti in vivo and both B. microti and Plasmodium falciparum in vitro. Several possible mechanisms for this observation are discussed.

authors

• Rice-Ficht, Allison

published proceedings

• Antimicrob Agents Chemother

altmetric score

• 0.75

author list (cited authors)

• Mintzer, C. L., Deloron, P., Rice-Ficht, A., Durica, D., Struck, D. K., Roessner, C. A., Nicolau, C., & Ihler, G. M.

citation count

• 1

complete list of authors

• Mintzer, CL||Deloron, P||Rice-Ficht, A||Durica, D||Struck, DK||Roessner, CA||Nicolau, C||Ihler, GM

publication date

• March 1988

publisher

• American Society for Microbiology  Publisher

published in

• Antimicrobial Agents and Chemotherapy  Journal

keywords

• Animals
• Babesiosis
• Erythrocytes
• Hemolysis
• In Vitro Techniques
• Malaria
• Mice
• Mice, Inbred BALB C
• Phytic Acid

Digital Object Identifier (DOI)

• 10.1128/AAC.32.3.391

URI

• https://hdl.handle.net/1969.1/181879

start page

• 391

end page

• 394

volume

• 32

issue

• 3

URL

• http://dx.doi.org/10.1128/aac.32.3.391