Intrinsically disordered proteins and multicellular organisms. Academic Article

abstract

• Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry out numerous biological functions, especially those associated with signaling, transcription regulation, DNA condensation, cell division, and cellular differentiation. Both post-translational modifications (PTMs) and alternative splicing (AS) expand the functional repertoire of IDPs. Here we propose that an "IDP-based developmental toolkit," which is comprised of IDP regions, PTMs, especially multiple PTMs, within these IDP regions, and AS events within segments of pre-mRNA that code for these same IDP regions, allows functional diversification and environmental responsiveness for molecules that direct the development of complex metazoans.

authors

• Bondos, Sarah

published proceedings

• Semin Cell Dev Biol

altmetric score

• 0.75

author list (cited authors)

• Dunker, A. K., Bondos, S. E., Huang, F., & Oldfield, C. J.

citation count

• 100

complete list of authors

• Dunker, A Keith||Bondos, Sarah E||Huang, Fei||Oldfield, Christopher J

publication date

• January 2015

publisher

• Elsevier  Publisher

published in

• Seminars in Cell and Developmental Biology  Journal

keywords

• Alternative Splicing
• Biological Evolution
• Cell Cycle
• Differentiation
• Eukaryotic Cells
• Intrinsic Disorder
• Intrinsically Disordered Proteins
• Post-translational Modification
• Prokaryotic Cells
• Protein Folding
• Protein Processing, Post-Translational
• Signaling

Digital Object Identifier (DOI)

• 10.1016/j.semcdb.2014.09.025

start page

• 44

end page

• 55

volume

• 37

URL

• http://dx.doi.org/10.1016/j.semcdb.2014.09.025