Biological functions of phosphatidylinositol transfer proteins. Academic Article uri icon


  • Phosphatidylinositol/phosphatidylcholine transfer proteins (PITPs) are ubiquitous and highly conserved proteins that are believed to regulate lipid-mediated signaling events. Their ubiquity and conservation notwithstanding, PITPs remain remarkably uninvestigated. Little is known about the coupling of specific PITPs to explicit cellular functions or the mechanisms by which PITPs interface with appropriate cellular functions. The available information indicates a role for these proteins in regulating the interface between lipid metabolism and membrane trafficking in yeast, signaling in plant development, the trafficking of specialized luminal cargo in mammalian enterocytes, and neurological function in mammals. Herein, we review recent advances in PITP biology and discuss as yet unresolved issues in this field.

published proceedings

  • Biochem Cell Biol

author list (cited authors)

  • Routt, S. M., & Bankaitis, V. A.

citation count

  • 52

complete list of authors

  • Routt, Sheri M||Bankaitis, Vytas A

publication date

  • February 2004