Transposon tools hopping in vertebrates. Academic Article

abstract

• In the past decade, tools derived from DNA transposons have made major contributions to vertebrate genetic studies from gene delivery to gene discovery. Multiple, highly complementary systems have been developed, and many more are in the pipeline. Judging which DNA transposon element will work the best in diverse uses from zebrafish genetic manipulation to human gene therapy is currently a complex task. We have summarized the major transposon vector systems active in vertebrates, comparing and contrasting known critical biochemical and in vivo properties, for future tool design and new genetic applications.

authors

• Clark, Karl

published proceedings

• Brief Funct Genomic Proteomic

author list (cited authors)

• Ni, J., Clark, K. J., Fahrenkrug, S. C., & Ekker, S. C.

complete list of authors

• Ni, Jun||Clark, Karl J||Fahrenkrug, Scott C||Ekker, Stephen C

publication date

• November 2008

publisher

• Oxford University Press (OUP)  Publisher

published in

• n2041-2649ISSN  Journal

keywords

• Animals
• DNA
• DNA Transposable Elements
• Gene Transfer Techniques
• Genetic Vectors
• Models, Biological
• Zebrafish

PubMed Central ID

• 19109308

Digital Object Identifier (DOI)

• 10.1093/bfgp/eln049

start page

• 444

end page

• 453

volume

• 7

issue

• 6

URL

• http://dx.doi.org/10.1093/bfgp/eln049