The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking.
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A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As Sec14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells.
author list (cited authors)
Mousley, C. J., Tyeryar, K. R., Vincent-Pope, P., & Bankaitis, V. A.
complete list of authors
Mousley, Carl J||Tyeryar, Kimberly R||Vincent-Pope, Patrick||Bankaitis, Vytas A