The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling. Academic Article

abstract

• Lipid signaling pathways define central mechanisms for cellular regulation. Productive lipid signaling requires an orchestrated coupling between lipid metabolism, lipid organization and the action of protein machines that execute appropriate downstream reactions. Using membrane trafficking control as primary context, we explore the idea that the Sec14-protein superfamily defines a set of modules engineered for the sensing of specific aspects of lipid metabolism and subsequent transduction of 'sensing' information to a phosphoinositide-driven 'execution phase'. In this manner, the Sec14 superfamily connects diverse territories of the lipid metabolome with phosphoinositide signaling in a productive 'crosstalk' between these two systems. Mechanisms of crosstalk, by which non-enzymatic proteins integrate metabolic cues with the action of interfacial enzymes, represent unappreciated regulatory themes in lipid signaling.

authors

• Bankaitis, Vytas

published proceedings

• Trends Biochem Sci

author list (cited authors)

• Bankaitis, V. A., Mousley, C. J., & Schaaf, G.

citation count

• 163

complete list of authors

• Bankaitis, Vytas A||Mousley, Carl J||Schaaf, Gabriel

publication date

• March 2010

publisher

• Elsevier  Publisher

published in

• n0968-0004ISSN  Journal

keywords

• Animals
• Cell Membrane
• Lipid Metabolism
• Models, Molecular
• Phosphatidylinositol Phosphates
• Phosphatidylinositols
• Phospholipid Transfer Proteins
• Phosphotransferases (Alcohol Group Acceptor)
• Protein Structure, Tertiary
• Saccharomyces Cerevisiae Proteins
• Signal Transduction

Digital Object Identifier (DOI)

• 10.1016/j.tibs.2009.10.008

start page

• 150

end page

• 160

volume

• 35

issue

• 3

URL

• http://dx.doi.org/10.1016/j.tibs.2009.10.008