Mammalian diseases of phosphatidylinositol transfer proteins and their homologs. Academic Article

abstract

• Inositol and phosphoinositide signaling pathways represent major regulatory systems in eukaryotes. The physiological importance of these pathways is amply demonstrated by the variety of diseases that involve derangements in individual steps in inositide and phosphoinositide production and degradation. These diseases include numerous cancers, lipodystrophies and neurological syndromes. Phosphatidylinositol transfer proteins (PITPs) are emerging as fascinating regulators of phosphoinositide metabolism. Recent advances identify PITPs (and PITP-like proteins) to be coincidence detectors, which spatially and temporally coordinate the activities of diverse aspects of the cellular lipid metabolome with phosphoinositide signaling. These insights are providing new ideas regarding mechanisms of inherited mammalian diseases associated with derangements in the activities of PITPs and PITP-like proteins.

authors

• Bankaitis, Vytas

published proceedings

• Clin Lipidol

author list (cited authors)

• Nile, A. H., Bankaitis, V. A., & Grabon, A.

citation count

• 44

complete list of authors

• Nile, Aaron H||Bankaitis, Vytas A||Grabon, Aby

publication date

• January 2010

publisher

• Taylor & Francis  Publisher

published in

• Clinical Lipidology and Metabolic Disorders  Journal

keywords

• Generic Health Relevance

Digital Object Identifier (DOI)

• 10.2217/clp.10.67

start page

• 867

end page

• 897

volume

• 5

issue

• 6

URL

• http://dx.doi.org/10.2217/clp.10.67