The oxysterol-binding protein superfamily: new concepts and old proteins. Academic Article

abstract

• The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN (trans-Golgi network) and endosomal membranes. We demonstrated recently that Kes1 acts as a sterol-regulated rheostat for TGN/endosomal phosphatidylinositol 4-phosphate signalling. Kes1 utilizes its dual lipid-binding activities to integrate endosomal lipid metabolism with TORC1 (target of rapamycin complex 1)-dependent proliferative pathways and transcriptional control of nutrient signalling.

authors

• Bankaitis, Vytas

published proceedings

• Biochem Soc Trans

author list (cited authors)

• Villasmil, M. L., Bankaitis, V. A., & Mousley, C. J.

citation count

• 11

complete list of authors

• Villasmil, Michelle L||Bankaitis, Vytas A||Mousley, Carl J

publication date

• April 2012

publisher

• Portland Press  Publisher

published in

• Biochemical Society Transactions  Journal

keywords

• Animals
• Endosomes
• Humans
• Multigene Family
• Receptors, Steroid
• Signal Transduction
• Sterols
• Trans-Golgi Network

PubMed Central ID

• 22435832

Digital Object Identifier (DOI)

• 10.1042/BST20120012

start page

• 469

end page

• 473

volume

• 40

issue

• 2

URL

• http://dx.doi.org/10.1042/bst20120012