The oxysterol-binding protein superfamily: new concepts and old proteins Academic Article uri icon

abstract

  • The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN (trans-Golgi network) and endosomal membranes. We demonstrated recently that Kes1 acts as a sterol-regulated rheostat for TGN/endosomal phosphatidylinositol 4-phosphate signalling. Kes1 utilizes its dual lipid-binding activities to integrate endosomal lipid metabolism with TORC1 (target of rapamycin complex 1)-dependent proliferative pathways and transcriptional control of nutrient signalling.

author list (cited authors)

  • Villasmil, M. L., Bankaitis, V. A., & Mousley, C. J.

citation count

  • 11

publication date

  • March 2012