Unsaturated fatty acid-induced non-canonical autophagy: unusual? Or unappreciated? Academic Article

abstract

• The breakdown of cellular components via autophagy is crucial for cellular homeostasis.In this issue of The EMBO Journal,Niso-Santano et al (2015) report the important observation that feeding cells with saturated or unsaturated fatty acids triggers mechanistically distinct autophagic responses. Feeding cells saturated fatty acid induced the canonical, BECN1/PI3K dependent autophagy pathway. Conversely,the unsaturated fatty acid oleate triggered autophagic responses that were independent of the BECN1/PI3K complex, but that required a functional Golgi system.

authors

• Bankaitis, Vytas

published proceedings

• EMBO J

altmetric score

• 9.5

author list (cited authors)

• Bankaitis, V. A.

citation count

• 5

complete list of authors

• Bankaitis, Vytas A

publication date

• April 2015

publisher

• EMBO  Publisher

published in

• EMBO Journal  Journal

keywords

• Animals
• Autophagy
• Fatty Acids, Unsaturated
• Female
• Humans

PubMed Central ID

• 25762589

Digital Object Identifier (DOI)

• 10.15252/embj.201591392

start page

• 978

end page

• 980

volume

• 34

issue

• 8

URL

• http://dx.doi.org/10.15252/embj.201591392