Overlap in the distribution of TrkB immunoreactivity and retinohypothalamic tract innervation of the rat suprachiasmatic nucleus. Academic Article

abstract

• Brain-derived neurotrophic factor (BDNF) may regulate the circadian sensitivity of the clock in the hypothalamic suprachiasmatic nucleus (SCN) to light, possibly by modulating retinohypothalamic tract (RHT) input. In the present study, the anatomical distribution of the cognate receptor for BDNF, the TrkB tyrosine kinase, in RHT fibers and the SCN of rats was analyzed using combined immunohistochemical and anterograde tracing methods. Fluorescent immunostaining for the TrkB receptor was evident in fibers and cell bodies throughout the SCN. Dual labeling analysis revealed that there was substantial overlap in the distribution of TrkB immunostaining and cholera toxin subunit B (CTB)-labeling within RHT terminals and fibers projecting from the optic chiasm to the ventrolateral SCN. The present results suggest that RHT fibers may express TrkB receptors and thus provide a paracrine target for BDNF-mediated regulation of photic input to the SCN.

authors

• Allen, Gregg
• Earnest, David

published proceedings

• Neurosci Lett

author list (cited authors)

• Allen, G. C., & Earnest, D. J.

citation count

• 18

complete list of authors

• Allen, Gregg C||Earnest, David J

publication date

• January 2005

publisher

• Elsevier  Publisher

published in

• NEUROSCIENCE LETTERS  Journal

keywords

• Animals
• Brain-derived Neurotrophic Factor
• Cholera Toxin
• Circadian Rhythm
• Fluorescent Antibody Technique
• Male
• Optic Chiasm
• Presynaptic Terminals
• Rats
• Rats, Sprague-Dawley
• Receptor, TrkB
• Retinal Ganglion Cells
• Suprachiasmatic Nucleus
• Visual Pathways

PubMed Central ID

• 15721221

Digital Object Identifier (DOI)

• 10.1016/j.neulet.2004.11.076

start page

• 200

end page

• 204

volume

• 376

issue

• 3

URL

• http://dx.doi.org/10.1016/j.neulet.2004.11.076