Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Academic Article

abstract

• The first non-hematopoietic mesenchymal stem cells (MSCs) were discovered by Friedenstein in 1976, who described clonal, plastic adherent cells from bone marrow capable of differentiating into osteoblasts, adipocytes, and chondrocytes. More recently, investigators have now demonstrated that multi-potent MSCs can be recovered from a variety of other adult tissues and differentiate into numerous tissue lineages including myoblasts, hepatocytes and possibly even neural tissue. Because MSCs are multipotent and easily expanded in culture, there has been much interest in their clinical potential for tissue repair and gene therapy and as a result, numerous studies have been carried out demonstrating the migration and multi-organ engraftment potential of MSCs in animal models and in human clinical trials. This review describes the recent advances in the understanding of MSC biology.

authors

• Gregory, Carl
• Prockop, Darwin

published proceedings

• Exp Cell Res

altmetric score

• 12

author list (cited authors)

• Gregory, C. A., Prockop, D. J., & Spees, J. L.

citation count

• 226

complete list of authors

• Gregory, Carl A||Prockop, Darwin J||Spees, Jeffrey L

publication date

• January 2005

publisher

• Elsevier  Publisher

published in

• Experimental Cell Research  Journal

keywords

• Animals
• Bone Marrow Cells
• Cell Differentiation
• Forecasting
• Humans
• Mesenchymal Stem Cells
• Multipotent Stem Cells
• Tissue Engineering

Digital Object Identifier (DOI)

• 10.1016/j.yexcr.2005.03.018

start page

• 330

end page

• 335

volume

• 306

issue

• 2

URL

• http://dx.doi.org/10.1016/j.yexcr.2005.03.018