Potential of modulating Wnt signaling pathway toward the development of bone anabolic agent. Academic Article

abstract

• Normal bone homeostasis is the result of a cross-talk between the anabolic axis (osteoblast differentiation) and catabolic axis (osteoclast remodeling). A disruption of this tightly regulated relationship leads to imbalanced bone turnover which ultimately results in diseases of the skeleton. Given that the majority of disease states are characterized by an inadequate renewal of osteoblasts, and the canonical wingless (Wnt) pathway is critical for their differentiation from progenitors, this represents an intriguing target for bone therapy. This mini-review focuses on the different options available for pharmaceutical enhancement of osteogenic differentiation through targeting the various proteins involved in Wnt signaling.

authors

• Gregory, Carl

published proceedings

• Curr Mol Pharmacol

author list (cited authors)

• Krause, U., & Gregory, C. A.

citation count

• 15

complete list of authors

• Krause, Ulf||Gregory, Carl A

publication date

• June 2012

publisher

• BENTHAM SCIENCE PUBLISHERS  Publisher

published in

• Current Molecular Pharmacology  Journal

keywords

• Anabolic Agents
• Bone And Bones
• Cell Differentiation
• Glycogen Synthase Kinase 3
• Glycogen Synthase Kinase 3 Beta
• Humans
• Osteogenesis
• PPAR Gamma
• Wnt Proteins
• Wnt Signaling Pathway

PubMed Central ID

• 21787289

Digital Object Identifier (DOI)

• 10.2174/1874467211205020164

start page

• 164

end page

• 173

volume

• 5

issue

• 2

URL

• http://dx.doi.org/10.2174/1874467211205020164