NanostructureDriven Indocyanine Green Dimerization Generates UltraStable Phototheranostics Nanoparticles Academic Article uri icon

abstract

  • AbstractIndocyanine green (ICG) is the only nearinfrared (NIR) dye approved for clinical use. Despite its versatility in photonic applications and potential for photothermal therapy, its photobleaching hinders its application. Here we discovered a nanostructure of dimeric ICG (NanodICG) generated by using ICG to stabilize nanoemulsions, after which ICG enabled complete dimerization on the nanoemulsion shell, followed by Jaggregation of ICGdimer, resulting in a narrow, redshifted (780nm894nm) and intense (2fold) absorbance. Compared to ICG, NanodICG demonstrated superior photothermal conversion (2fold higher), significantly reduced photodegradation (9.6% vs. 46.3%), and undiminished photothermal effect (7 vs. 2cycles) under repeated irradiations, in addition to excellent colloidal and structural stabilities. Following intravenous injection, NanodICG enabled realtime tracking of its delivery to mouse tumors within 24h by photoacoustic imaging at NIR wavelength (890nm) distinct from the endogenous signal to guide effective photothermal therapy. The unprecedented finding of nanostructuredriven ICG dimerization leads to an ultrastable phototheranostic platform.

published proceedings

  • Angewandte Chemie

author list (cited authors)

  • Kwon, N., Jasinevicius, G. O., Kassab, G., Ding, L., Bu, J., Martinelli, L. P., ... Buzz, H. H.

complete list of authors

  • Kwon, Nahyun||Jasinevicius, Gabriel O||Kassab, Giulia||Ding, Lili||Bu, Jiachuan||Martinelli, Letícia P||Ferreira, Vinicius G||Dhaliwal, Alexander||Chan, Harley HL||Mo, Yulin||Bagnato, Vanderlei S||Kurachi, Cristina||Chen, Juan||Zheng, Gang||Buzzá, Hilde H

publication date

  • July 2023

publisher