The systemic effects of lasers have been observed for a long time. Despite a huge amount of evidence, its foundations are still being systematically investigated with several scientific experiments. As the metabolism in animals is systemic by nature, it should come as no surprise that localized excitation of molecules leads to generalized reactions, which can contribute to the rehabilitation of many diseases. As a new area of research, clinical cases presentations generate evidence for more in-depth fundamental studies. In this work, we report some different clinical cases, demonstrating the value of photobiomodulation in systematic situations. A collection of cases where vascular systemic photobiomodulation were employed are presented and inflammatory markers area evaluated. All cases considered are known to have long treatment and difficult results. The results presented with vascular systemic photobiomodulation are relevant in the considered to improve quality of life, stimulus for its use in general and as a motivation for in-depth studies in the area.
