Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation. Academic Article uri icon

abstract

  • BACKGROUND: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. CASE: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy. CONCLUSION: SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Supplementary file1 (MP4 8441 KB).

published proceedings

  • Drugs R D

author list (cited authors)

  • Rogers, S., Silva, P. J., Udeani, G., Deleon, M., Mutyala, S., Panahi, L., ... Ramos, K. S.

citation count

  • 1

complete list of authors

  • Rogers, Sara||Silva, Patrick J||Udeani, George||Deleon, Monica||Mutyala, Sriarchala||Panahi, Ladan||Abu-Baker, Asim||Neal, Gabriel||Ramos, Kenneth S

publication date

  • February 2024