Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. Academic Article uri icon

abstract

  • Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABAA receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25-20 mg/kg, s.c.) causes a dose-dependent suppression of behavioral and electrographic seizures in fully amygdala-kindled female mice, with nearly complete seizure protection at the highest dose tested. The ED50 for suppression of behavioral seizures was 6.6 mg/kg. The seizure suppression produced by ganaxolone was comparable to that of clonazepam (ED50, 0.1 mg/kg, s.c.). To the extent that amygdala kindling represents a model of mesial temporal lobe epilepsy, this study supports the utility of ganaxolone in the treatment of patients with temporal lobe seizures.

published proceedings

  • Epilepsy Res

altmetric score

  • 6

author list (cited authors)

  • Reddy, D. S., & Rogawski, M. A.

citation count

  • 64

complete list of authors

  • Reddy, Doodipala S||Rogawski, Michael A

publication date

  • May 2010