Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? Academic Article uri icon


  • Endogenous neurosteroids affect brain excitability during physiological states such as pregnancy and the menstrual cycle, and during conditions of acute and chronic stress. The neurosteroid allotetrahydrodeoxycorticosterone (THDOC) is an allosteric modulator of the GABA(A) receptor. Although the role of THDOC within the brain is undefined, recent studies indicate that stress induces THDOC to levels that can activate GABA(A) receptors. These results might have significant implications for human stress-sensitive conditions such as epilepsy, post-traumatic stress disorder and depression.

published proceedings

  • Trends Pharmacol Sci

altmetric score

  • 3

author list (cited authors)

  • Reddy, D. S.

citation count

  • 99

complete list of authors

  • Reddy, Doodipala S

publication date

  • March 2003