Papillomavirus E1 proteins: form, function, and features. Academic Article

abstract

• The E1 proteins are the essential origin recognition proteins for papillomavirus (PV) replication. E1 proteins bind to specific DNA elements in the viral origin of replication and assemble into hexameric helicases with the aid of a second viral protein, E2. The resultant helicase complex initiates origin DNA unwinding to provide the template for subsequent syntheses of progeny DNA. In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase alpha and RPA. This review will compare the basic structures and features of the human (HPV) and bovine (BPV1) papillomaviruses with an emphasis on mechanisms of replication function.

authors

• Wilson, Van

published proceedings

• Virus Genes

altmetric score

• 0.25

author list (cited authors)

• Wilson, V. G., West, M., Woytek, K., & Rangasamy, D.

citation count

• 94

complete list of authors

• Wilson, Van G||West, Michael||Woytek, Kelly||Rangasamy, Dandapani

publication date

• January 2002

publisher

• Springer Nature  Publisher

published in

• Virus Genes  Journal

keywords

• Adenosine Triphosphatases
• Animals
• Bovine Papillomavirus 1
• DNA Helicases
• DNA-Binding Proteins
• Humans
• Papillomaviridae
• Protein Biosynthesis
• Protein Processing, Post-Translational
• Viral Proteins

Digital Object Identifier (DOI)

• 10.1023/a:1015336817836

start page

• 275

end page

• 290

volume

• 24

issue

• 3

URL

• http://dx.doi.org/10.1023/a:1015336817836