Differentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents. Academic Article uri icon


  • The ability of commercially available amino acid derivatives, especially Fmoc-Trp(Boc)-OH, to differentiate enantiomers of chiral phosphonates, phosphinates, phosphates, phosphine oxides, and phosphonamidates is demonstrated with (31)P, (13)C, and (1)H NMR spectroscopy. The chiral differentiation provided a rapid and convenient method for measuring the enantiomeric purity of these phosphorus compounds.

published proceedings

  • Tetrahedron Asymmetry

author list (cited authors)

  • Li, Y., & Raushel, F. M.

citation count

  • 23

complete list of authors

  • Li, Yingchun||Raushel, Frank M

publication date

  • January 2007