Insulin Dysregulated Horses Metabolic Responses to Forage Pellets.
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abstract
Hyperinsulinemia-associated laminitis (HAL) is the primary concern for insulin dysregulated (ID) equids and their insulin response to the consumption of oral, nonstructural carbohydrates (NSC) has been shown to be a risk predictor for HAL development. This randomized, crossover study's objective was to examine the insulinemic responses to 3 forage pellets (1 g/kg BW) (timothy hay, TH, 9.5% CP & 10% NSC DM; alfalfa hay, AH, 16.3% CP & 9.8% NSC DM; timothy-alfalfa hay; TAH, 17.2% CP & 9.8% NSC DM) along with a positive (dehulled oats; OG, 14.7% CP & 59.7% NSC DM) and negative dietary challenge control (low-NSC; LNSC, 12.8% CP & 5.4% NSC DM) of ID (n=8; 16.12.2 yr; 565.499.1 kgs.) and non-ID (NID; n=7; 17.02.8 yr; 583.657.9 kgs.) horses. ID horses had higher positive incremental area under the curve for insulin (IAUCi) (ID: 890925 IU/mL*minute vs. NID: 225228 IU/mL*minute), peak (ID: 101.580.72 IU/mL vs. NID: 25.77.2 IU/mL), and delta (ID: 45.577.1 IU/mL vs. NID: 4.95.3 IU/mL) insulin for all forage pellets compared to NID (p<0.01). ID horses IAUCi for the forage pellets was not different compared to the LNSC (218327 IU/mL*minute) but was different from OG (10,5224,565 IU/mL*minute). ID horses' lack of an augmented insulinemic response to thelow NSC forage pellets(fed in small amounts) indicates that theycould be a safe feedstuff for ID animals.
