Nramp1 deletion does not confer susceptibility to Rhodococcus equi infection in mice. Academic Article

abstract

• Rhodococcus equi is an intracellular bacterium that causes pneumonia in immunocompromised people and foals. The Nramp1 gene influences susceptibility to a variety of intracellular bacteria (including mycobacterial species), but not to Mycobacterium tuberculosis. In this study, we demonstrate that mice functionally deleted of the Nramp1 gene were not more susceptible to infection with virulent R. equi (ATCC 33701) than wild-type mice. Susceptibility of mice to infection with the intracellular bacterium R. equi is more similar to that of M. tuberculosis than to other intracellular bacteria, including other mycobacteria.

authors

• Cohen, Noah

published proceedings

• Immunogenetics

author list (cited authors)

• Cohen, N. D., Harrington, J., Gros, P., Del Castro, L., Meyer, D., & Martens, R. J.

citation count

• 5

complete list of authors

• Cohen, Noah D||Harrington, Jessica||Gros, Philippe||Del Castro, Lucero||Meyer, Dianna||Martens, Ronald J

publication date

• April 2004

publisher

• Springer Nature  Publisher

published in

• Immunogenetics  Journal

keywords

• Actinomycetales Infections
• Animals
• Cation Transport Proteins
• Colony Count, Microbial
• Gene Deletion
• Horses
• Humans
• Mice
• Mice, Knockout
• Rhodococcus Equi
• Virulence

PubMed Central ID

• 15045472

Digital Object Identifier (DOI)

• 10.1007/s00251-004-0670-5

start page

• 65

end page

• 67

volume

• 56

issue

• 1

URL

• http://dx.doi.org/10.1007/s00251-004-0670-5