Regulation of Macronutrients in Insulin Resistance and Glucose Homeostasis during Type 2 Diabetes Mellitus. Academic Article

abstract

• Insulin resistance is an important feature of metabolic syndrome and a precursor of type 2 diabetes mellitus (T2DM). Overnutrition-induced obesity is a major risk factor for the development of insulin resistance and T2DM. The intake of macronutrients plays a key role in maintaining energy balance. The components of macronutrients distinctly regulate insulin sensitivity and glucose homeostasis. Precisely adjusting the beneficial food compound intake is important for the prevention of insulin resistance and T2DM. Here, we reviewed the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, including fructose, dietary fiber, saturated and unsaturated fatty acids, and amino acids. Understanding the diet-gene interaction will help us to better uncover the molecular mechanisms of T2DM and promote the application of precision nutrition in practice by integrating multi-omics analysis.

authors

• Guo, Shaodong

published proceedings

• Nutrients

author list (cited authors)

• Yang, W., Jiang, W., & Guo, S.

complete list of authors

• Yang, Wanbao||Jiang, Wen||Guo, Shaodong

publication date

• November 2023

publisher

• MDPI  Publisher

published in

• Nutrients  Journal

keywords

• Diabetes Mellitus, Type 2
• Glucose
• Glucose Homeostasis
• Homeostasis
• Humans
• Insulin
• Insulin Resistance
• Macronutrients
• Nutrients
• Type 2 Diabetes Mellitus

PubMed Central ID

• 37960324

Digital Object Identifier (DOI)

• 10.3390/nu15214671

start page

• 4671

end page

• 4671

volume

• 15

issue

• 21

URL

• http://dx.doi.org/10.3390/nu15214671