Synthesis of an Indazole/Indazolium Phosphine Ligand Scaffold and Its Application in Gold(I) Catalysis. Academic Article

abstract

• Advances in ligand development have allowed for the fine-tuning of gold catalysis. To contribute to this field, we designed an indazole phosphine ligand scaffold that allows facile introduction of cationic charge through methylation. With minimal changes to the structure upon methylation, we could assess the importance of the electronic effects of the insertion of a positive charge on the catalytic activity of the resulting gold(I) complex. Using the benchmark reactions of propargyl amide cyclization and enyne cyclization with and without hexafluoroisopropanol (HFIP), we observed marked differences in the catalytic activities of the neutral and cationic gold species.

authors

• Gabbai, Francois

published proceedings

• Organometallics

author list (cited authors)

• Munawar, A., Maltz, L. T., Liu, W., & Gabbai, F. P.

citation count

• 0

complete list of authors

• Munawar, Asima||Maltz, Logan T||Liu, Wei-Chun||Gabbaiï, François P

publication date

• October 2023

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organometallics  Journal

keywords

• 34 Chemical Sciences
• 3402 Inorganic Chemistry

PubMed Central ID

• 38357473

Digital Object Identifier (DOI)

• 10.1021/acs.organomet.3c00354

start page

• 2742

end page

• 2746

volume

• 42

issue

• 19

URL

• http://dx.doi.org/10.1021/acs.organomet.3c00354