Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization. Academic Article uri icon

abstract

  • Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

published proceedings

  • J Am Chem Soc

author list (cited authors)

  • Lin, L. Y., Tiemann, K. M., Li, Y., Pinkner, J. S., Walker, J. N., Hultgren, S. J., Hunstad, D. A., & Wooley, K. L.

citation count

  • 8

complete list of authors

  • Lin, Lily Yun||Tiemann, Kristin M||Li, Yali||Pinkner, Jerome S||Walker, Jennifer N||Hultgren, Scott J||Hunstad, David A||Wooley, Karen L

publication date

  • March 2012