Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization. Academic Article

abstract

• Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

authors

• Wooley, Karen

published proceedings

• J Am Chem Soc

author list (cited authors)

• Lin, L. Y., Tiemann, K. M., Li, Y., Pinkner, J. S., Walker, J. N., Hultgren, S. J., Hunstad, D. A., & Wooley, K. L.

citation count

• 8

complete list of authors

• Lin, Lily Yun||Tiemann, Kristin M||Li, Yali||Pinkner, Jerome S||Walker, Jennifer N||Hultgren, Scott J||Hunstad, David A||Wooley, Karen L

publication date

• March 2012

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of the American Chemical Society  Journal

keywords

• Adhesins, Escherichia Coli
• Epithelial Cells
• Escherichia Coli
• Fimbriae Proteins
• Models, Molecular
• Nanoparticles
• Particle Size
• Polymers
• Surface Properties

PubMed Central ID

• 22360307

Digital Object Identifier (DOI)

• 10.1021/ja2091917

start page

• 3938

end page

• 3941

volume

• 134

issue

• 9

URL

• http://dx.doi.org/10.1021/ja2091917