Synthetic Polymer Nanoparticles Conjugated with FimHA from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization
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abstract
Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.