Photodisinfection of material surfaces and bacterial skin infections by a detergent loaded with curcumin.

abstract

• The development of technologies and therapeutic strategies is needed to combat skin infections and pathogenic microorganisms present on material surfaces that are still responsible for serious public health problems. In this study, detergents loaded with curcumin were prepared by a simple approach and characterized by UV-vis spectroscopy and fluorescence spectroscopy. Their antibacterial photodynamic effects were evaluated against Staphylococcus aureus in planktonic medium and in vivo (skin infection model), and showed a reduction up to 8 logs and 2 logs, respectively. Additionally, the curcumin-detergents were applied on photodisinfection of material surfaces such as wood, rubber, and stainless steel resulting in an efficient photoinactivation up to 3 logs. These developed detergents loaded with curcumin can improve the decontamination of material surfaces and skin infections (in vivo) when illuminated.

authors

• Bagnato, Vanderlei

published proceedings

• Photodiagnosis Photodyn Ther

author list (cited authors)

• Dias, L. D., Alves, F., Buzza, H. H., & Bagnato, V. S.

complete list of authors

• Dias, Lucas D||Dias, Lucas D||Alves, Fernanda||Alves, Fernanda||Buzza, Hilde H||Buzza, Hilde H||Bagnato, Vanderlei S||Bagnato, Vanderlei S

publication date

• September 2022

publisher

• Elsevier  Publisher

published in

• Photodiagnosis and Photodynamic Therapy  Journal

keywords

• Anti-Bacterial Agents
• Antimicrobial Photodynamic Therapy
• Curcumin
• Detergent
• Detergents
• Humans
• Photochemotherapy
• Photodisinfection
• Skin Diseases, Bacterial
• Staphylococcus Aureus
• Surface
• Wound

PubMed Central ID

• 35850462

Digital Object Identifier (DOI)

• 10.1016/j.pdpdt.2022.103021

start page

• 103021

end page

• 103021

volume

• 39

URL

• http://dx.doi.org/10.1016/j.pdpdt.2022.103021