Mechanisms in 2-hexanone potentiation of chloroform hepatotoxicity. Academic Article

abstract

• 2-Hexanone (2-Hx) is known to potentiate chloroform (CHCl3) hepatotoxicity in part by increasing the bioactivation of CHCl3 to phosgene (COCl2). Treatment of rats with 2-Hx + CHCl3 in vivo did not initiate peroxidation of hepatic fatty acids as determined by formation of conjugated dienes or depletion of unsaturated fatty acids, or as determined by production of malondialdehyde (MDA) in vitro. A 5-fold decrease in the specific activity of succinate-dependent cytochrome c reductase in liver from rats treated in vivo with corn oil (vehicle) + CHCl3 and in rats treated with 2-Hx + CHCl3 indicated that a mechanism independent of CHCl3 bioactivation may add to the hepatotoxic effects which result from the metabolism of chloroform to phosgene.

authors

• Schroeder, Friedhelm

published proceedings

• Toxicol Lett

author list (cited authors)

• Cowlen, M. S., Hewitt, W. R., & Schroeder, F.

citation count

• 4

complete list of authors

• Cowlen, MS||Hewitt, WR||Schroeder, F

publication date

• September 1984

publisher

• Elsevier  Publisher

published in

• Toxicology Letters  Journal

keywords

• Animals
• Biotransformation
• Chloroform
• Drug Synergism
• Ketones
• Lipid Peroxides
• Liver
• Male
• Methyl N-butyl Ketone
• Nadph-ferrihemoprotein Reductase
• Rats
• Rats, Inbred F344
• Succinate Cytochrome C Oxidoreductase

PubMed Central ID

• 6091297

Digital Object Identifier (DOI)

• 10.1016/0378-4274(84)90104-8

start page

• 293

end page

• 299

volume

• 22

issue

• 3

URL

• http://dx.doi.org/10.1016/0378-4274(84)90104-8