The inheritance pattern of factor XII (Hageman) deficiency in domestic cats. Academic Article uri icon

abstract

  • Measurements of coagulation factor XII levels in F1 progeny of a cat having factor XII deficiency revealed an autosomal recessive pattern similar to that reported in humans (Hageman trait). A study of the pedigree of the colony revealed that F1 kittens had approximately 50% factor XII activity while kittens produced by backcrossing with an F1 progeny possessed an average of 50% and a less than 2% factor XII activity in an approximate 1:1 ratio. Kittens having an average of 50% factor XII activity were postulated heterozygous for the trait while progeny with less than 2% activity were considered genetically homozygous.

published proceedings

  • Can J Comp Med

author list (cited authors)

  • Kier, A. B., Bresnahan, J. F., White, F. J., & Wagner, J. E.

citation count

  • 26

complete list of authors

  • Kier, AB||Bresnahan, JF||White, FJ||Wagner, JE

publication date

  • July 1980