Dietary Nanocurcumin Impacts Blood Biochemical Parameters and Works Synergistically with Florfenicol in African Catfish Challenged with Aeromonas veronii Academic Article uri icon


  • The present study investigated the effects of dietary supplementation of nanocurcumin (NCur = 150 ppm) in African catfish feed for 15 days along with two doses of florfenicola therapeutic dose (FFC1 = 10 mg/kg.BW) and a high dose (FFC2 = 30 mg/kg.BW). Serum biochemical parameters and histopathological changes in liver and kidney tissues were determined post-feeding. Additionally, fish were experimentally challenged with a virulent strain of Aeromonas veronii to explore the fishs capacity to resist infections. Results indicated that the serum level of total protein was significantly elevated in the FFC2 + Ncur group compared with control, Ncur, and FFC2 groups. Total protein level was also higher in FFC1 + Ncur compared with that of the FFC1 group. Moreover, feeding NCur, FFC1 + Ncur, and FFC2 + Ncur resulted in a significant increase in globulin levels compared to control, FFC1, and FFC2-Fed groups. However, the albumin level was unaffected. Serum levels of AST, ALT, ALP, and urea significantly increased in FFC2-fed fish compared to controls indicating liver damage. The higher dosage of FFC2 induced histological alterations in the liver and kidney architecture, represented by a rupture of the central vein, cytoplasmic vacuolation, hepatocytes necrosis, and severe inflammation. Surprisingly, NCur inclusion improved most of the altered biochemical parameters and mitigated FFC-induced histological damage in the hepatic and renal tissues. Similarly, fish that were fed a combination of both FFC and Ncur showed a higher resistance when exposed to A. veronii infection, as the mortality rates were significantly lower than those of the control group. Our findings indicated that incorporating NCur into the diet can have multiple benefits for the sustainable aquaculture of African catfish. These advantages encompass mitigating drug-induced damage to the liver and kidney tissues, augmenting the therapeutic efficacy of FFC in a synergistic manner and providing protection against A. veronii infections.

published proceedings


altmetric score

  • 0.25

author list (cited authors)

  • Mansour, S., Bakry, K. A., Alwaleed, E. A., Ahmed, H., Al-Amgad, Z., Mohammed, H. H., & Emeish, W.

citation count

  • 2

complete list of authors

  • Mansour, Salwa||Bakry, Karima A||Alwaleed, Eman A||Ahmed, Hassan||Al-Amgad, Zeinab||Mohammed, Haitham H||Emeish, Walaa FA

publication date

  • 2023


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