- 2014 by John Wiley & Sons, Inc. All rights reserved. This chapter highlights how beef production methods keep residues low and discusses potential sources of violative residues in beef cattle, including disease incidence, typical pharmacotherapeutic programs, and risky practices. It presents descriptions of programs that reduce those risks and makes recommendations on best practices to lower the risk of residues in edible beef. The most important step in reducing residues of drugs and chemicals in beef is to utilize anti-infectives only when necessary. The use of drugs to treat animals with disease is a necessary and humane practice in animal production. The goal of minimization of antimicrobial use must be accompanied by the commitment to use antimicrobials when they are necessary. With the increasing concern worldwide for resistance to all chemical groups of parasiticides, considerable scientific data have been collected on controlling parasites using production practices rather than drugs.