Neuroendocrine insights into neurosteroid therapy for postpartum depression.

abstract

• Postpartum depression (PPD) is associated with a decline in progesterone-derived anxiolytic-antidepressant neurosteroids after delivery. Neurosteroid replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) shows promise as the first drug treatment for PPD. Here we describe the molecular insights of the neurosteroid approach for rapid relief of PPD symptoms compared with traditional antidepressants.

authors

• Reddy, Samba

published proceedings

• Trends Mol Med

altmetric score

• 7.75

author list (cited authors)

• Reddy, D. S.

citation count

• 2

complete list of authors

• Reddy, Doodipala Samba

publication date

• August 2023

publisher

• Elsevier  Publisher

published in

• n1471-4914ISSN  Journal

keywords

• Allopregnanolone
• Brexanolone
• Depression
• GABA-A Receptor
• Neurosteroid
• Tonic Inhibition

PubMed Central ID

• 37541828

Digital Object Identifier (DOI)

• 10.1016/j.molmed.2023.07.006

start page

• S1471-4914(23)00156-9

URL

• http://dx.doi.org/10.1016/j.molmed.2023.07.006