Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease.

abstract

• Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.

authors

• Schroeder, Friedhelm

published proceedings

• Lipids

author list (cited authors)

• Wood, W. G., Schroeder, F., Avdulov, N. A., Chochina, S. V., & Igbavboa, U.

citation count

• 100

complete list of authors

• Wood, WG||Schroeder, F||Avdulov, NA||Chochina, SV||Igbavboa, U

publication date

• March 1999

publisher

• Wiley  Publisher

published in

• Lipids  Journal

keywords

• Alzheimer Disease
• Animals
• Biological Transport
• Brain
• Carrier Proteins
• Cell Membrane
• Cholesterol
• Humans
• Lipid Metabolism

PubMed Central ID

• 10230715

Digital Object Identifier (DOI)

• 10.1007/s11745-999-0357-9

start page

• 225

end page

• 234

volume

• 34

issue

• 3

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000079541200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff