Is inflammatory bowel disease in dogs and cats associated with a Th1 or Th2 polarization? Academic Article

abstract

• Mucosal immunity involves complex interactions to generate either immune tolerance or active immune responses. An imbalance of pro- and anti-inflammatory cytokines and chemokines that drive the recruitment of immune cells to the intestinal mucosa are a key characteristic of inflammatory bowel disease in humans, where distinctive helper-T-lymphocyte profiles help to discriminate between Crohn's disease and ulcerative colitis. This review evaluates the current veterinary literature to determine whether a Th1/Th2 (and possibly also Th17) polarization also exists in canine and feline inflammatory bowel disease.

authors

• Suchodolski, Jan

published proceedings

• Vet Immunol Immunopathol

altmetric score

• 0.75

author list (cited authors)

• Heilmann, R. M., & Suchodolski, J. S.

citation count

• 16

complete list of authors

• Heilmann, Romy M||Suchodolski, Jan S

publication date

• December 2015

publisher

• Elsevier  Publisher

published in

• Veterinary Immunology and Immunopathology  Journal

keywords

• Animals
• Canine
• Cat Diseases
• Cats
• Chronic Enteropathy
• Dog Diseases
• Dogs
• Inflammatory Bowel Disease
• Inflammatory Bowel Diseases
• Th1
• Th1 Cells
• Th17
• Th17 Cells
• Th2
• Th2 Cells

PubMed Central ID

• 26672910

Digital Object Identifier (DOI)

• 10.1016/j.vetimm.2015.10.008

start page

• 131

end page

• 134

volume

• 168

issue

• 3-4

URL

• http://dx.doi.org/10.1016/j.vetimm.2015.10.008