Intestinal and liver fatty acid binding proteins differentially affect fatty acid uptake and esterification in L-cells. Academic Article

abstract

• Differential effects of intestinal (I-FABP) or liver (L-FABP) fatty acid binding proteins on fatty acid uptake and esterification were examined using transfected mouse L-cell fibroblasts. L-FABP, but not I-FABP, expression increased the initial rate and extent of cis-parinaric acid uptake by 50 and 29%, respectively, compared to control cells. I-FABP and L-FABP expression preferentially increased [3H]-oleic acid incorporation into triacylglycerols by 5.5-fold and 3.8-fold, respectively. While both L-FABP and I-FABP increased esterification of [3H]-oleic acid into ethanolamine glycerophospholipids, these proteins had opposite effect on esterification into choline glycerophospholipids. These data show for the first time that distinct FABP differentially affect both fatty acid uptake and intracellular esterification.

authors

• Schroeder, Friedhelm

published proceedings

• Lipids

author list (cited authors)

• Prows, D. R., Murphy, E. J., & Schroeder, F.

citation count

• 112

complete list of authors

• Prows, DR||Murphy, EJ||Schroeder, F

publication date

• October 1995

publisher

• Wiley  Publisher

keywords

• Animals
• Carrier Proteins
• Esterification
• Fatty Acid-binding Protein 7
• Fatty Acid-binding Proteins
• Fatty Acids
• Fatty Acids, Unsaturated
• Gene Expression
• Intestines
• Kinetics
• L Cells
• Liver
• Mice
• Myelin P2 Protein
• Neoplasm Proteins
• Nerve Tissue Proteins
• Oleic Acid
• Oleic Acids
• Phosphatidylcholines
• Phosphatidylethanolamines
• Transfection
• Triglycerides

Digital Object Identifier (DOI)

• 10.1007/BF02537481

start page

• 907

end page

• 910

volume

• 30

issue

• 10

URL

• http://dx.doi.org/10.1007/bf02537481