Liver and intestinal fatty acid binding proteins in control and TGF beta 1 gene targeted deficient mice. uri icon

abstract

  • The effect of transforming growth factor beta-1 (TGF beta 1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGF beta 1-deficient mice. Homozygous TGF beta 1-deficient 129 x CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGF beta 1-deficient/immunodeficient C3H mice on a SCID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGF beta 1-deficient/immunodeficient C3H mice only. Thus, TGF beta 1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively.

published proceedings

  • Mol Cell Biochem

author list (cited authors)

  • Fontaine, R. N., Gossett, R. E., Schroeder, F., O'Toole, B. A., Doetschman, T., & Kier, A. B.

citation count

  • 6

complete list of authors

  • Fontaine, RN||Gossett, RE||Schroeder, F||O'Toole, BA||Doetschman, T||Kier, AB

publication date

  • June 1996