A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity. Academic Article uri icon

abstract

  • Enabling and constraining immune activation is of fundamental importance in maintaining cellular homeostasis. Depleting BAK1 and SERK4, the co-receptors of multiple pattern recognition receptors (PRRs), abolishes pattern-triggered immunity but triggers intracellular NOD-like receptor (NLR)-mediated autoimmunity with an elusive mechanism. By deploying RNAi-based genetic screens in Arabidopsis, we identified BAK-TO-LIFE 2 (BTL2), an uncharacterized receptor kinase, sensing BAK1/SERK4 integrity. BTL2 induces autoimmunity through activating Ca2+ channel CNGC20 in a kinase-dependent manner when BAK1/SERK4 are perturbed. To compensate for BAK1 deficiency, BTL2 complexes with multiple phytocytokine receptors, leading to potent phytocytokine responses mediated by helper NLR ADR1 family immune receptors, suggesting phytocytokine signaling as a molecular link connecting PRR- and NLR-mediated immunity. Remarkably, BAK1 constrains BTL2 activation via specific phosphorylation to maintain cellular integrity. Thus, BTL2 serves as a surveillance rheostat sensing the perturbation of BAK1/SERK4 immune co-receptors in promoting NLR-mediated phytocytokine signaling to ensure plant immunity.

published proceedings

  • Cell

author list (cited authors)

  • Yu, X., Xie, Y., Luo, D., Liu, H., de Oliveira, M., Qi, P., ... Shan, L.

complete list of authors

  • Yu, Xiao||Xie, Yingpeng||Luo, Dexian||Liu, Hai||de Oliveira, Marcos VV||Qi, Peipei||Kim, Sung-Il||Ortiz-Morea, Fausto Andres||Liu, Jun||Chen, Yafei||Chen, Sixue||Rodrigues, Bárbara||Li, Bo||Xue, Shaowu||He, Ping||Shan, Libo

publication date

  • May 2023